Biofluids and Biomaterials

Understanding flow and spatial effects on blood coagulation using computational fluid dynamics

Christian Biscombe, Dalton Harvie, Ineke Muir (CSL) and Steve Dower (CSL)

Christian performed an AMSI Internship in collaboration with CSL on this topic. AMSI Internships are a national Australian initiative designed specifically to partner Industry with relevant research expertise in Australian universities. The Internships run for typically 4 months and are intended to help industry address a specific issue by providing mathematical expertise from the intern and the academic supervisor.

We are now performing a larger Australian Research Council Linkage Project ('Sticky cells: Understanding and modeling platelet flow and binding in blood') in this area, in collaboration with CSL Behring and RMIT University. We are looking for PhD students in this area - see Positions.

Occluded femoral artery
Above: The initiation of clotting in response to surface bound tissue-factor (TF) at an occluded femoral artery branch. Mesh courtesy Marchandise et. al., Int. J. Numer. Meth. Biomed. Engng. 2010; 83:876–889

Using Computational Fluid Dynamics to calculate the transport properties of bone and scaffold materials

Christian Daish (RMIT), Romane Blanchard (St. Vincents and Unimelb), Dalton Harvie, Peter Pivonka (QUT)

In collaboration with Christian, Romane and Peter, we have been developing methods to efficiently and accurately calculate macro-scale permeabilities and diffusitivies of porous materials from scan data (eg, microCT scans).

Above: Simulation of the fluid velocity through a periodic section of a bone sample, scanned using microCT and computed using a modified Volume of Fluid technique. The simulations were conducted using the network flow templates available within our open-source arb MFD software.

Publications

6 results
2018
[6]Lift forces on a sphere in bounded and wall-bounded flows (; ; ; ; and ), . [bibtex]
2017
[5]Mechanical and Fluid Dynamical Characterization of 3d Porous Ceramic Material – Application to Baghdadite Scaffolds for Large Segmental Bone Defects (; ; ; ; and ), . [bibtex]
2016
[4] Estimation of anisotropic permeability in trabecular bone based on microCT imaging and pore-scale fluid dynamics simulations (; ; ; ; ; and ), In Bone Reports, . [bibtex] [pdf] [doi]
[3]Trabecular bone anisotropic permeability based on micro-ct imaging and upscaling of porescale fluid flow (; ; ; ; ; and ), . [bibtex]
[2]Steady-state corneal oxygen consumption profiles during contact lens wear ( and ), . [bibtex]
2012
[1]Steady-state oxygen consumption profiles in the cornea ( and ), . [bibtex]